House of Gucci is inspired by the family empire behind the Italian fashion house of Gucci. When Patrizia Reggiani (Lady Gaga), an outsider from humble beginnings, marries into the Gucci family, her unbridled ambition begins to unravel the family legacy and triggers a reckless spiral of betrayal, decadence, revenge, and ultimately...murder.

In Rome, the America tourist Hayley meets the local lawyer Michelangelo on the street and soon they fall in love with each other. Hayley's parents, the psychiatrist Phyllis and the retired music producer Jerry, travel to Rome to meet Michelangelo and his parents. When Jerry listens to Michelangelo's father Giancarlo singing opera in the shower, he is convinced that he is a talented opera singer. But there is a problem: Giancarlo can only sing in the shower. The couple Antonio and Milly travel to...

One day at a colleague's going away party, Anna meets Domenico, a virile, slightly older chap who's married with two small kids. Passion's flames are rapidly kindled and result in steamy encounters.